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7nwj
From Proteopedia
(Difference between revisions)
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==Solution NMR structure of the N-terminal domain of CEP164 (1-109)== | ==Solution NMR structure of the N-terminal domain of CEP164 (1-109)== | ||
| - | <StructureSection load='7nwj' size='340' side='right'caption='[[7nwj | + | <StructureSection load='7nwj' size='340' side='right'caption='[[7nwj]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7nwj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NWJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nwj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NWJ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nwj OCA], [https://pdbe.org/7nwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nwj RCSB], [https://www.ebi.ac.uk/pdbsum/7nwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nwj ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nwj OCA], [https://pdbe.org/7nwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nwj RCSB], [https://www.ebi.ac.uk/pdbsum/7nwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nwj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/CE164_HUMAN CE164_HUMAN] Senior-Loken syndrome. The disease is caused by variants affecting the gene represented in this entry. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CE164_HUMAN CE164_HUMAN] Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.<ref>PMID:17954613</ref> <ref>PMID:18283122</ref> <ref>PMID:23348840</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Rutherford TJ]] | |
| - | [[Category: Rutherford | + | [[Category: Van Breugel M]] |
| - | [[Category: | + | |
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Current revision
Solution NMR structure of the N-terminal domain of CEP164 (1-109)
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