1rvt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1rvt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVT FirstGlance]. <br> | <table><tr><td colspan='2'>[[1rvt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVT FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvt OCA], [https://pdbe.org/1rvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvt RCSB], [https://www.ebi.ac.uk/pdbsum/1rvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvt OCA], [https://pdbe.org/1rvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvt RCSB], [https://www.ebi.ac.uk/pdbsum/1rvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q82500_9INFA Q82500_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013828_004_327643][RuleBase:RU003324] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Unidentified influenza virus]] | [[Category: Unidentified influenza virus]] | ||
| - | [[Category: Daniels | + | [[Category: Daniels RS]] |
| - | [[Category: Gamblin | + | [[Category: Gamblin SJ]] |
| - | [[Category: Ha | + | [[Category: Ha Y]] |
| - | [[Category: Haire | + | [[Category: Haire LF]] |
| - | [[Category: Russell | + | [[Category: Russell RJ]] |
| - | [[Category: Skehel | + | [[Category: Skehel JJ]] |
| - | [[Category: Steinhauer | + | [[Category: Steinhauer DA]] |
| - | [[Category: Stevens | + | [[Category: Stevens DJ]] |
| - | [[Category: Vasisht | + | [[Category: Vasisht N]] |
| - | [[Category: Xiao | + | [[Category: Xiao B]] |
| - | + | ||
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Revision as of 06:08, 23 August 2023
1930 H1 Hemagglutinin in complex with LSTC
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