1sis
From Proteopedia
(Difference between revisions)
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==SPATIAL STRUCTURE OF INSECTOTOXIN I5A BUTHUS EUPEUS BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (RUSSIAN)== | ==SPATIAL STRUCTURE OF INSECTOTOXIN I5A BUTHUS EUPEUS BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (RUSSIAN)== | ||
| - | <StructureSection load='1sis' size='340' side='right'caption='[[1sis | + | <StructureSection load='1sis' size='340' side='right'caption='[[1sis]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1sis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1sis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SIS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sis OCA], [https://pdbe.org/1sis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sis RCSB], [https://www.ebi.ac.uk/pdbsum/1sis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sis ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sis OCA], [https://pdbe.org/1sis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sis RCSB], [https://www.ebi.ac.uk/pdbsum/1sis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sis ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CTX5A_MESEU CTX5A_MESEU] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buthus eupeus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mesobuthus eupeus]] |
| - | [[Category: | + | [[Category: Arseniev AS]] |
| - | [[Category: | + | [[Category: Bystrov VF]] |
| - | [[Category: | + | [[Category: Kondakov VI]] |
| - | [[Category: | + | [[Category: Lomize AL]] |
| - | [[Category: | + | [[Category: Maiorov VN]] |
Revision as of 21:36, 28 June 2023
SPATIAL STRUCTURE OF INSECTOTOXIN I5A BUTHUS EUPEUS BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (RUSSIAN)
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