7ew4
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein== |
| - | <StructureSection load='7ew4' size='340' side='right'caption='[[7ew4]]' scene=''> | + | <StructureSection load='7ew4' size='340' side='right'caption='[[7ew4]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ew4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EW4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ew4 OCA], [https://pdbe.org/7ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ew4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JF9:~{N},~{N}-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide'>JF9</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ew4 OCA], [https://pdbe.org/7ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ew4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Transducin 3D structures|Transducin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Shao ZH]] |
| + | [[Category: Wang HL]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Zhao C]] | ||
Current revision
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
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Categories: Homo sapiens | Large Structures | Shao ZH | Wang HL | Wang W | Zhao C
