1c3d
From Proteopedia
(New page: 200px<br /> <applet load="1c3d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c3d, resolution 1.80Å" /> '''X-RAY CRYSTAL STRUC...) |
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| - | [[Image:1c3d.gif|left|200px]]<br /> | + | [[Image:1c3d.gif|left|200px]]<br /><applet load="1c3d" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1c3d" size=" | + | |
caption="1c3d, resolution 1.80Å" /> | caption="1c3d, resolution 1.80Å" /> | ||
'''X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2'''<br /> | '''X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Activation and covalent attachment of complement component C3 to pathogens | + | Activation and covalent attachment of complement component C3 to pathogens is the key step in complement-mediated host defense. Additionally, the antigen-bound C3d fragment interacts with complement receptor 2 (CR2; also known as CD21) on B cells and thereby contributes to the initiation of an acquired humoral response. The x-ray crystal structure of human C3d solved at 2.0 angstroms resolution reveals an alpha-alpha barrel with the residues responsible for thioester formation and covalent attachment at one end and an acidic pocket at the other. The structure supports a model whereby the transition of native C3 to its functionally active state involves the disruption of a complementary domain interface and provides insight into the basis for the interaction between C3d and CR2. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1C3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1C3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3D OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Diefenbach, R | + | [[Category: Diefenbach, R J.]] |
| - | [[Category: Isenman, D | + | [[Category: Isenman, D E.]] |
| - | [[Category: Jones, R | + | [[Category: Jones, R G.]] |
[[Category: Nagar, B.]] | [[Category: Nagar, B.]] | ||
| - | [[Category: Rini, J | + | [[Category: Rini, J M.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: alpha-alpha barrel]] | [[Category: alpha-alpha barrel]] | ||
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[[Category: complement]] | [[Category: complement]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:59 2008'' |
Revision as of 10:01, 21 February 2008
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X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2
Contents |
Overview
Activation and covalent attachment of complement component C3 to pathogens is the key step in complement-mediated host defense. Additionally, the antigen-bound C3d fragment interacts with complement receptor 2 (CR2; also known as CD21) on B cells and thereby contributes to the initiation of an acquired humoral response. The x-ray crystal structure of human C3d solved at 2.0 angstroms resolution reveals an alpha-alpha barrel with the residues responsible for thioester formation and covalent attachment at one end and an acidic pocket at the other. The structure supports a model whereby the transition of native C3 to its functionally active state involves the disruption of a complementary domain interface and provides insight into the basis for the interaction between C3d and CR2.
Disease
Known diseases associated with this structure: C3 deficiency OMIM:[120700], Macular degeneration, age-related, 9 OMIM:[120700]
About this Structure
1C3D is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2., Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM, Science. 1998 May 22;280(5367):1277-81. PMID:9596584
Page seeded by OCA on Thu Feb 21 12:01:59 2008
Categories: Homo sapiens | Single protein | Diefenbach, R J. | Isenman, D E. | Jones, R G. | Nagar, B. | Rini, J M. | GOL | Alpha-alpha barrel | C3 | C3d | Complement
