6zlv

<table><tr><td colspan='2'>[[6zlv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZLV FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mreC, GNQ20_16665 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/A0A6A9K3A1_PSEAI A0A6A9K3A1_PSEAI]] Involved in formation and maintenance of cell shape.[PIRNR:PIRNR038471]

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== Publication Abstract from PubMed ==

The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell wall biosynthesis enzymes, in a process that may be dependent on MreC self-association. Here, we use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC from Pseudomonas aeruginosa in atomic detail. MreC monomers interact in head-to-tail fashion. Longitudinal and lateral interfaces are essential for oligomerization in vitro, and a phylogenetic analysis of proteobacterial MreC sequences indicates the prevalence of the identified interfaces. Our results are consistent with a model where MreC's ability to alternate between self-association and interaction with the cell wall biosynthesis machinery plays a key role in the regulation of elongasome activity.

Self-association of MreC as a regulatory signal in bacterial cell wall elongation.,Martins A, Contreras-Martel C, Janet-Maitre M, Miyachiro MM, Estrozi LF, Trindade DM, Malospirito CC, Rodrigues-Costa F, Imbert L, Job V, Schoehn G, Attree I, Dessen A Nat Commun. 2021 May 20;12(1):2987. doi: 10.1038/s41467-021-22957-9. PMID:34016967<ref>PMID:34016967</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Contreras-Martel, C]]

[[Category: Estrozi, L F]]

[[Category: Structural protein]]