1t60
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T60 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T60 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [https://pdbe.org/1t60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [https://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [https://pdbe.org/1t60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [https://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CO4A1_BOVIN CO4A1_BOVIN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.[UniProtKB:P02463] Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.[UniProtKB:P02462] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bondar | + | [[Category: Bondar O]] |
| - | [[Category: Friedman | + | [[Category: Friedman DB]] |
| - | [[Category: Hudson | + | [[Category: Hudson BG]] |
| - | [[Category: Shanmugasundararaj | + | [[Category: Shanmugasundararaj S]] |
| - | [[Category: Sundaramoorthy | + | [[Category: Sundaramoorthy M]] |
| - | [[Category: Vanacore | + | [[Category: Vanacore RM]] |
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Revision as of 06:26, 23 August 2023
Crystal structure of Type IV collagen NC1 domain from bovine lens capsule
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