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== Disease ==
== Disease ==
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Influenza A causes the infectious respiratory disease Influenza, more commonly known as the Flu.<ref>PMID:29955068</ref> Influenza has several symptoms associated with it: fever, sore throat, runny nose, headache, muscle pain, and fatigue to severe and in some cases lethal pneumonia resultant from either influenza virus or bacterial infection in the lower respiratory tract.<ref>PMID:29955068</ref> The CDC estimated in 2019-2020 that the overall burden of Influenza was 35 million Flu-related illnesses, 16 million Flu-related medical visits, 380,000 Flu-related hospitalizations, and 20,000 Flu-related deaths [https://www.cdc.gov/flu/about/burden/2019-2020.html]. The WHO estimated the global impact of annual Flu epidemics resulted in 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths [https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal)].
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Influenza A causes the infectious respiratory disease Influenza, more commonly known as the Flu.<ref>PMID:29955068</ref> Influenza has several symptoms associated with it: fever, sore throat, runny nose, headache, muscle pain, and fatigue to severe and in some cases lethal pneumonia resultant from either influenza virus or bacterial infection in the lower respiratory tract.<ref>PMID:29955068</ref> The CDC estimated in 2019-2020 that the overall burden of Influenza was 35 million Flu-related illnesses, 16 million Flu-related medical visits, 380,000 Flu-related hospitalizations, and 20,000 Flu-related deaths [https://www.cdc.gov/flu/about/burden/2019-2020.html]. The WHO estimated the global impact of annual Flu epidemics resulted in 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths [https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal)]. Multiple types of vaccines against Influenza currently exist: inactivated influenza vaccines (IIV4s), recombinant influenza vaccine (RIV4), and live attenuated influenza vaccine (LAIV4).<ref>PMID:34448800</ref>
== Structure ==
== Structure ==

Revision as of 23:38, 5 October 2021

Influenza A RNA-Dependent RNA Polymerase

PDB ID 6RR7

Drag the structure with the mouse to rotate

References

  1. ↑ Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garcia-Sastre A. Influenza. Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. PMID:29955068 doi:http://dx.doi.org/10.1038/s41572-018-0002-y
  2. ↑ Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garcia-Sastre A. Influenza. Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. PMID:29955068 doi:http://dx.doi.org/10.1038/s41572-018-0002-y
  3. ↑ Grohskopf LA, Alyanak E, Ferdinands JM, Broder KR, Blanton LH, Talbot HK, Fry AM. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021-22 Influenza Season. MMWR Recomm Rep. 2021 Aug 27;70(5):1-28. doi: 10.15585/mmwr.rr7005a1. PMID:34448800 doi:http://dx.doi.org/10.15585/mmwr.rr7005a1
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