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7b2t
From Proteopedia
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| - | ==== | + | ==Crystal structure of Iripin-5 serpin from Ixodes ricinus== |
| - | <StructureSection load='7b2t' size='340' side='right'caption='[[7b2t]]' scene=''> | + | <StructureSection load='7b2t' size='340' side='right'caption='[[7b2t]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7b2t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B2T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b2t OCA], [https://pdbe.org/7b2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b2t RCSB], [https://www.ebi.ac.uk/pdbsum/7b2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b2t ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b2t OCA], [https://pdbe.org/7b2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b2t RCSB], [https://www.ebi.ac.uk/pdbsum/7b2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b2t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Iripin-5 is the main Ixodes ricinus salivary serpin, which acts as a modulator of host defence mechanisms by impairing neutrophil migration, suppressing nitric oxide production by macrophages and altering complement functions. Iripin-5 influences host immunity and shows high expression in the salivary glands. Here, the crystal structure of Iripin-5 in the most thermodynamically stable state of serpins is described. In the reactive-centre loop, the main substrate-recognition site of Iripin-5 is likely to be represented by Arg342, which implies the targeting of trypsin-like proteases. Furthermore, a computational structural analysis of selected Iripin-5-protease complexes together with interface analysis revealed the most probable residues of Iripin-5 involved in complex formation. | ||
| + | |||
| + | Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus.,Kascakova B, Kotal J, Martins LA, Berankova Z, Langhansova H, Calvo E, Crossley JA, Havlickova P, Dycka F, Prudnikova T, Kuty M, Kotsyfakis M, Chmelar J, Kuta Smatanova I Acta Crystallogr D Struct Biol. 2021 Sep 1;77(Pt 9):1183-1196. doi: , 10.1107/S2059798321007920. Epub 2021 Aug 23. PMID:34473088<ref>PMID:34473088</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7b2t" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Serpin 3D structures|Serpin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ixodes scapularis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Kascakova B]] |
| + | [[Category: Kuta Smatanova I]] | ||
Current revision
Crystal structure of Iripin-5 serpin from Ixodes ricinus
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