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7d2k
From Proteopedia
(Difference between revisions)
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==Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a== | ==Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a== | ||
| - | <StructureSection load='7d2k' size='340' side='right'caption='[[7d2k]]' scene=''> | + | <StructureSection load='7d2k' size='340' side='right'caption='[[7d2k]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D2K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7d2k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D2K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2k OCA], [https://pdbe.org/7d2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2k RCSB], [https://www.ebi.ac.uk/pdbsum/7d2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2k ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GQC:1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium'>GQC</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d2k OCA], [https://pdbe.org/7d2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d2k RCSB], [https://www.ebi.ac.uk/pdbsum/7d2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d2k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Nadezhdin | + | [[Category: Nadezhdin, K D]] |
| - | [[Category: Neuberger A]] | + | [[Category: Neuberger, A]] |
| - | [[Category: | + | [[Category: Singh, A K]] |
| - | [[Category: | + | [[Category: Sobolevsky, A I]] |
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein-inhibitor complex]] | ||
| + | [[Category: Trp channel]] | ||
Revision as of 20:13, 20 October 2021
Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a
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