7jzo
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALTPP== |
| - | <StructureSection load='7jzo' size='340' side='right'caption='[[7jzo]]' scene=''> | + | <StructureSection load='7jzo' size='340' side='right'caption='[[7jzo]], [[Resolution|resolution]] 1.61Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7jzo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JZO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzo OCA], [https://pdbe.org/7jzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzo RCSB], [https://www.ebi.ac.uk/pdbsum/7jzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzo ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QTU:3-(thiophen-2-yl)propanoic+acid'>QTU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jzo OCA], [https://pdbe.org/7jzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jzo RCSB], [https://www.ebi.ac.uk/pdbsum/7jzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jzo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Synthetic construct]] |
| + | [[Category: Gill NP]] | ||
| + | [[Category: Madden DR]] | ||
Current revision
CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALTPP
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