1fch

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{{STRUCTURE_1fch| PDB=1fch | SCENE= }}
{{STRUCTURE_1fch| PDB=1fch | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5'''
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===CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5===
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==Overview==
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Many proteins contain targeting signals within their sequences that specify their delivery to particular organelles. The peroxisomal targeting signal-1 (PTS1) is a C-terminal tripeptide that is sufficient to direct proteins into peroxisomes. The PTS1 sequence closely approximates Ser-Lys-Leu-COO-. PEX5, the receptor for PTS1, interacts with the signal via a series of tetratricopeptide repeats (TPRs) within its C-terminal half. Here we report the crystal structure of a fragment of human PEX5 that includes all seven predicted TPR motifs in complex with a pentapeptide containing a PTS1 sequence. Two clusters of three TPRs almost completely surround the peptide, while a hinge region, previously identified as TPR4, forms a distinct structure that enables the two sets of TPRs to form a single binding site. This structure reveals the molecular basis for PTS1 recognition and demonstrates a novel mode of TPR-peptide interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 11101887 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101887}}
==About this Structure==
==About this Structure==
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[[Category: Tetratricopeptide repeat]]
[[Category: Tetratricopeptide repeat]]
[[Category: Tpr]]
[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:10:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:02:52 2008''

Revision as of 00:02, 1 July 2008

Image:1fch.png

Template:STRUCTURE 1fch

CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5

Template:ABSTRACT PUBMED 11101887

About this Structure

1FCH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5., Gatto GJ Jr, Geisbrecht BV, Gould SJ, Berg JM, Nat Struct Biol. 2000 Dec;7(12):1091-5. PMID:11101887

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