1fcj

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{{STRUCTURE_1fcj| PDB=1fcj | SCENE= }}
{{STRUCTURE_1fcj| PDB=1fcj | SCENE= }}
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'''CRYSTAL STRUCTURE OF OASS COMPLEXED WITH CHLORIDE AND SULFATE'''
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===CRYSTAL STRUCTURE OF OASS COMPLEXED WITH CHLORIDE AND SULFATE===
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==Overview==
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A new crystal structure of O-acetylserine sulfhydrylase (OASS) has been solved with chloride bound at an allosteric site and sulfate bound at the active site. The bound anions result in a new "inhibited" conformation, that differs from the "open" native or "closed" external aldimine conformations. The allosteric site is located at the OASS dimer interface. The new inhibited structure involves a change in the position of the "moveable domain" (residues 87-131) to a location that differs from that in the open or closed forms. Formation of the external aldimine with substrate is stabilized by interaction of the alpha-carboxyl group of the substrate with a substrate-binding loop that is part of the moveable domain. The inhibited conformation prevents the substrate-binding loop from interacting with the alpha-carboxyl group, and hinders formation of the external Schiff base and thus subsequent chemistry. Chloride may be an analog of sulfide, the physiological inhibitor. Finally, these results suggest that OASS represents a new class of PLP-dependent enzymes that is regulated by small anions.
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(as it appears on PubMed at http://www.pubmed.gov), where 11023792 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11023792}}
==About this Structure==
==About this Structure==
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[[Category: Tai, C.]]
[[Category: Tai, C.]]
[[Category: Homodimer]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:10:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:03:02 2008''

Revision as of 00:03, 1 July 2008

Image:1fcj.png

Template:STRUCTURE 1fcj

CRYSTAL STRUCTURE OF OASS COMPLEXED WITH CHLORIDE AND SULFATE

Template:ABSTRACT PUBMED 11023792

About this Structure

1FCJ is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound., Burkhard P, Tai CH, Jansonius JN, Cook PF, J Mol Biol. 2000 Oct 20;303(2):279-86. PMID:11023792

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