1zuz

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Current revision (08:15, 25 October 2023) (edit) (undo)
 
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<StructureSection load='1zuz' size='340' side='right'caption='[[1zuz]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='1zuz' size='340' side='right'caption='[[1zuz]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZUZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZUZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wrz|1wrz]], [[1yr5|1yr5]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zuz OCA], [https://pdbe.org/1zuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zuz RCSB], [https://www.ebi.ac.uk/pdbsum/1zuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zuz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zuz OCA], [https://pdbe.org/1zuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zuz RCSB], [https://www.ebi.ac.uk/pdbsum/1zuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zuz ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kursula, P]]
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[[Category: Kursula P]]
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[[Category: Vahokoski, J]]
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[[Category: Vahokoski J]]
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[[Category: Wilmanns, M]]
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[[Category: Wilmanns M]]
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[[Category: Ef-hand]]
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[[Category: Metal binding protein-transferase complex]]
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[[Category: Phosphorylation-mimicking point mutation]]
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Current revision

Calmodulin in complex with a mutant peptide from human DRP-1 kinase

PDB ID 1zuz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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