Sandbox Reserved 1687

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<StructureSection load='Ebola_RDRP_Model.pdb' size='320' color='black' frame='true' side='right' caption='Ebola Virus RNA-Dependent RNA Polymerase' scene=''>
<StructureSection load='Ebola_RDRP_Model.pdb' size='320' color='black' frame='true' side='right' caption='Ebola Virus RNA-Dependent RNA Polymerase' scene=''>
==Disease==
==Disease==
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A specific DNA complex of the 65-residue, N-terminal fragment of the yeast transcriptional activator, GAL4, has been analysed at 2.7 A resolution by X-ray crystallography. The protein binds as a dimer to a symmetrical 17-base-pair sequence. A small, Zn(2+)-containing domain recognizes a conserved CCG triplet at each end of the site through direct contacts with the major groove. A short coiled-coil dimerization element imposes 2-fold symmetry. A segment of extended polypeptide chain links the metal-binding module to the dimerization element and specifies the length of the site. The relatively open structure of the complex would allow another protein to bind coordinately with GAL4.
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Ebola virus (EBOV) causes Ebola virus disease (EVD), a fatal hemorrhagic disease discovered in 1976 (Furuyama & Marzi, 2019). Sources of infection are mainly linked with “hunting wildlife, exposure to animal carcasses found in the forest, or contact with the putative virus reservoir, bats” (Furuyama & Marzi, 2019).
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EVD pathogenesis in humans consists of three phases with symptoms normally occurring after an incubation period of 2-21 says (Furuyama & Marzi, 2019). In the first phase, symptoms during the first few days include nonspecific fever, headache, and myalgia (Furuyama & Marzi, 2019). This is followed by a “gastrointestinal phase” characterized by symptoms including diarrhea, vomiting, abdominal discomfort, and dehydration (Furuyama & Marzi, 2019). The final and advanced phase of the illness consist of kidney and liver function failure, often resulting in “metabolic compromise, convulsion, shock, and death due to mucosal bleeding, bloody diarrhea, and multi-organ failure within 16 days after the first symptoms appear” (Furuyama & Marzi, 2019).
EVD pathogenesis in humans consists of three phases with symptoms normally occurring after an incubation period of 2-21 says (Furuyama & Marzi, 2019). In the first phase, symptoms during the first few days include nonspecific fever, headache, and myalgia (Furuyama & Marzi, 2019). This is followed by a “gastrointestinal phase” characterized by symptoms including diarrhea, vomiting, abdominal discomfort, and dehydration (Furuyama & Marzi, 2019). The final and advanced phase of the illness consist of kidney and liver function failure, often resulting in “metabolic compromise, convulsion, shock, and death due to mucosal bleeding, bloody diarrhea, and multi-organ failure within 16 days after the first symptoms appear” (Furuyama & Marzi, 2019).

Revision as of 22:45, 11 October 2021

Ebola Virus RNA-Dependent RNA Polymerase

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References

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