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Antagonists
From Proteopedia
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<StructureSection load='4dkl' size='400' side='right' caption='Crystal structure of the mu-opioid receptor bound to a morphinan antagonist, cholesterol, PEG 400, sulfate, mono-oleoyl-glycerol and Cl- ion (PDB entry [[4dkl]])' scene=4dkl/Overall_structure/1''> | <StructureSection load='4dkl' size='400' side='right' caption='Crystal structure of the mu-opioid receptor bound to a morphinan antagonist, cholesterol, PEG 400, sulfate, mono-oleoyl-glycerol and Cl- ion (PDB entry [[4dkl]])' scene=4dkl/Overall_structure/1''> | ||
'''Under construction''' | '''Under construction''' | ||
| + | See also [[Types of ligands]] and [[Signal transduction]]. | ||
| + | |||
Ligands that bind to a receptor but fail to activate the physiological response are receptor '''antagonists'''. | Ligands that bind to a receptor but fail to activate the physiological response are receptor '''antagonists'''. | ||
Revision as of 13:20, 13 October 2021
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References
- ↑ Turski L, Huth A, Sheardown M, McDonald F, Neuhaus R, Schneider HH, Dirnagl U, Wiegand F, Jacobsen P, Ottow E. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10960-5. PMID:9724812
- ↑ Walters MR, Kaste M, Lees KR, Diener HC, Hommel M, De Keyser J, Steiner H, Versavel M. The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study. Cerebrovasc Dis. 2005;20(5):304-9. Epub 2005 Aug 30. PMID:16131799 doi:10.1159/000087929
