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3img
From Proteopedia
(Difference between revisions)
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<StructureSection load='3img' size='340' side='right'caption='[[3img]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3img' size='340' side='right'caption='[[3img]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3img]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3img]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IMG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ2:1-BENZOFURAN-2-CARBOXYLIC+ACID'>BZ2</scene>, <scene name='pdbligand=BZ3:5-METHOXY-1H-INDOLE'>BZ3</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ2:1-BENZOFURAN-2-CARBOXYLIC+ACID'>BZ2</scene>, <scene name='pdbligand=BZ3:5-METHOXY-1H-INDOLE'>BZ3</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3img FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3img OCA], [https://pdbe.org/3img PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3img RCSB], [https://www.ebi.ac.uk/pdbsum/3img PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3img ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3img FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3img OCA], [https://pdbe.org/3img PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3img RCSB], [https://www.ebi.ac.uk/pdbsum/3img PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3img ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Pantoate--beta-alanine ligase]] | ||
| - | [[Category: Abell, C]] | ||
| - | [[Category: Blundell, T L]] | ||
| - | [[Category: Ciulli, A]] | ||
| - | [[Category: Hung, A W]] | ||
| - | [[Category: Silvestre, H L]] | ||
| - | [[Category: Wen, S]] | ||
| - | [[Category: Atp-binding]] | ||
| - | [[Category: Drug design]] | ||
| - | [[Category: Enzyme]] | ||
| - | [[Category: Fragment-based]] | ||
| - | [[Category: Ligase]] | ||
| - | [[Category: Magnesium]] | ||
| - | [[Category: Metal-binding]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Abell C]] |
| - | [[Category: | + | [[Category: Blundell TL]] |
| + | [[Category: Ciulli A]] | ||
| + | [[Category: Hung AW]] | ||
| + | [[Category: Silvestre HL]] | ||
| + | [[Category: Wen S]] | ||
Current revision
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid
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