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3jvx
From Proteopedia
(Difference between revisions)
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<StructureSection load='3jvx' size='340' side='right'caption='[[3jvx]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3jvx' size='340' side='right'caption='[[3jvx]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3jvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JVX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKB:6-ETHYL-5-[3-(3,4,5-TRIMETHOXYPHENYL)PROP-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>EKB</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKB:6-ETHYL-5-[3-(3,4,5-TRIMETHOXYPHENYL)PROP-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>EKB</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jvx OCA], [https://pdbe.org/3jvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jvx RCSB], [https://www.ebi.ac.uk/pdbsum/3jvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jvx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jvx OCA], [https://pdbe.org/3jvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jvx RCSB], [https://www.ebi.ac.uk/pdbsum/3jvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jvx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bacillus anthracis]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Anderson | + | [[Category: Anderson AC]] |
| - | [[Category: Beierlein | + | [[Category: Beierlein JM]] |
| - | [[Category: Karri | + | [[Category: Karri NG]] |
| - | + | ||
Current revision
Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
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