7nux

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<StructureSection load='7nux' size='340' side='right'caption='[[7nux]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='7nux' size='340' side='right'caption='[[7nux]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7nux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7nux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUX FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR1, KIAA0012 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nux OCA], [https://pdbe.org/7nux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nux RCSB], [https://www.ebi.ac.uk/pdbsum/7nux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nux ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nux OCA], [https://pdbe.org/7nux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nux RCSB], [https://www.ebi.ac.uk/pdbsum/7nux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nux ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN]] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7nux" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7nux" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Borshchevskiy, V I]]
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[[Category: Borshchevskiy VI]]
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[[Category: Luginina, A P]]
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[[Category: Luginina AP]]
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[[Category: Lushpa, V A]]
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[[Category: Lushpa VA]]
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[[Category: Mineev, K S]]
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[[Category: Mineev KS]]
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[[Category: Shevtsov, M B]]
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[[Category: Shevtsov MB]]
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[[Category: Vakhrameev, D D]]
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[[Category: Vakhrameev DD]]
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[[Category: Signaling protein]]
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[[Category: Tir domain]]
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[[Category: Toll-like receptor]]
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Revision as of 12:40, 1 February 2024

Crystal structure of the TIR domain of human TLR1 (crystallised without ZN2+ ions)

PDB ID 7nux

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