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1w9a

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Current revision (13:32, 9 May 2024) (edit) (undo)
 
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<StructureSection load='1w9a' size='340' side='right'caption='[[1w9a]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1w9a' size='340' side='right'caption='[[1w9a]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9A FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9a OCA], [https://pdbe.org/1w9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9a RCSB], [https://www.ebi.ac.uk/pdbsum/1w9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9a OCA], [https://pdbe.org/1w9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9a RCSB], [https://www.ebi.ac.uk/pdbsum/1w9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Y1155_MYCTU Y1155_MYCTU]] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
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[https://www.uniprot.org/uniprot/F420R_MYCTU F420R_MYCTU] F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo (PubMed:27364382). Binds coenzyme F420, but does not bind FMN or other flavins (PubMed:25644473). Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates (PubMed:25644473).<ref>PMID:25644473</ref> <ref>PMID:27364382</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Pyridoxal 5'-phosphate synthase]]
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[[Category: Bourne Y]]
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[[Category: Bourne, Y]]
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[[Category: Cambillau C]]
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[[Category: Cambillau, C]]
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[[Category: Cannan S]]
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[[Category: Cannan, S]]
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[[Category: Frassinetti F]]
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[[Category: Frassinetti, F]]
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[[Category: Maurien D]]
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[[Category: Maurien, D]]
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[[Category: Roig-Zamboni V]]
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[[Category: Roig-Zamboni, V]]
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[[Category: Scappuccini L]]
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[[Category: Scappuccini, L]]
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[[Category: Sulzenbacher G]]
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[[Category: Sulzenbacher, G]]
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[[Category: Oxidoreductase]]
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[[Category: Related to fmn-binding protein]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of Rv1155 from Mycobacterium tuberculosis

PDB ID 1w9a

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