1fgb

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[[Image:1fgb.gif|left|200px]]
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{{Seed}}
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[[Image:1fgb.png|left|200px]]
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{{STRUCTURE_1fgb| PDB=1fgb | SCENE= }}
{{STRUCTURE_1fgb| PDB=1fgb | SCENE= }}
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'''TOXIN'''
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===TOXIN===
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==Overview==
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Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio cholera, induces a profuse secretory diarrhea in susceptible hosts. Choleragenoid, the B subunit pentamer of cholera toxin, directs the enzymatic A subunit to its target by binding the GM1 gangliosides exposed on the luminal surface of intestinal epithelial cells. The crystal structure of choleragenoid has been independently solved and refined at 2.4 A resolution by combining single isomorphous replacement with non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence of the A subunit the central cavity of the B pentamer is a highly solvated channel. The binding of choleragenoid to the A subunit or to its receptor pentasaccharide modestly affects the local stereochemistry without perceptibly altering the subunit interface.
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The line below this paragraph, {{ABSTRACT_PUBMED_7658472}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7658472 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7658472}}
==About this Structure==
==About this Structure==
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[[Category: Choleragenoid]]
[[Category: Choleragenoid]]
[[Category: Enterotoxin]]
[[Category: Enterotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:17:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:12:27 2008''

Revision as of 00:12, 1 July 2008

Image:1fgb.png

Template:STRUCTURE 1fgb

TOXIN

Template:ABSTRACT PUBMED 7658472

About this Structure

1FGB is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid., Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG, J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:7658472

Page seeded by OCA on Tue Jul 1 03:12:27 2008

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