7eft
From Proteopedia
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==Crystal structure of cell shape-determining protein MreC== | ==Crystal structure of cell shape-determining protein MreC== | ||
| - | <StructureSection load='7eft' size='340' side='right'caption='[[7eft]]' scene=''> | + | <StructureSection load='7eft' size='340' side='right'caption='[[7eft]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EFT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7eft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EFT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eft OCA], [https://pdbe.org/7eft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eft RCSB], [https://www.ebi.ac.uk/pdbsum/7eft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eft ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eft OCA], [https://pdbe.org/7eft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eft RCSB], [https://www.ebi.ac.uk/pdbsum/7eft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eft ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MreC is a scaffold protein required for cell shape determination through interactions with proteins related to cell wall synthesis. Here, we determined the crystal structure of the major periplasmic part of MreC from Escherichia coli at 2.1 A resolution. The periplasmic part of MreC contains a coiled coil domain and two six-stranded barrel domains. The coiled coil domain is essential for dimer formation, and the two monomers are prone to relative motion that is related to the small interface of beta-barrel domains. In addition, MreC forms an antiparallel filament-like structure along the coiled coil direction, which is different to the helical array structure in Pseudomonas aeruginosa. Our structure deepens our understanding of polymer formation of MreC. | ||
| + | |||
| + | The crystal structure of MreC provides insights into polymer formation.,Xu Q, Sun N, Xiao Q, Huang CY, Xu M, Zhang W, Li L, Wang Q, Olieric V, Wang W, He J, Sun B FEBS Open Bio. 2021 Sep 12. doi: 10.1002/2211-5463.13296. PMID:34510818<ref>PMID:34510818</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7eft" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Sun B]] | + | [[Category: Sun, B]] |
| - | [[Category: Xiao | + | [[Category: Xiao, Q J]] |
| - | [[Category: Xu Q]] | + | [[Category: Xu, Q]] |
| + | [[Category: Dimer]] | ||
| + | [[Category: Filament-like structure]] | ||
| + | [[Category: Scaffold protein]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 10:54, 16 February 2022
Crystal structure of cell shape-determining protein MreC
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