1fh5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fh5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fh5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fh5| PDB=1fh5 | SCENE= }}
{{STRUCTURE_1fh5| PDB=1fh5 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33'''
+
===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33===
-
==Overview==
+
<!--
-
The Fab fragment of the murine monoclonal antibody, MAK33, directed against human creatine kinase of the muscle-type, was crystallized and the three-dimensional structure was determined to 2.9 A. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding large antigens. The structure allows us to analyze the environment of cis-prolyl-peptide bonds whose isomerization is of key importance in the folding process. These residues seem to be involved with not only domain stability but also seem to play a role in the association of heavy and light chains, reinforcing the importance of beta-strand recognition in antibody assembly. The structure also allows the localization of segments of primary sequence postulated to represent binding sites for the ER-specific chaperone BiP within the context of the entire Fab fragment. These sequences are found primarily in beta-strands that are necessary for interactions between the individual domains.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11036070}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11036070 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11036070}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Fab]]
[[Category: Fab]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:19:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:32 2008''

Revision as of 00:14, 1 July 2008

Image:1fh5.png

Template:STRUCTURE 1fh5

CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33

Template:ABSTRACT PUBMED 11036070

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip., Augustine JG, de La Calle A, Knarr G, Buchner J, Frederick CA, J Biol Chem. 2001 Feb 2;276(5):3287-94. Epub 2000 Oct 17. PMID:11036070

Page seeded by OCA on Tue Jul 1 03:14:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fh5"
Personal tools