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3bbp

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Current revision (12:06, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3bbp' size='340' side='right'caption='[[3bbp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3bbp' size='340' side='right'caption='[[3bbp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bbp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BBP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bbp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BBP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gil|2gil]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GCC2, KIAA0336, RANBP2L4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bbp OCA], [https://pdbe.org/3bbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bbp RCSB], [https://www.ebi.ac.uk/pdbsum/3bbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bbp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bbp OCA], [https://pdbe.org/3bbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bbp RCSB], [https://www.ebi.ac.uk/pdbsum/3bbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bbp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[https://www.uniprot.org/uniprot/GCC2_HUMAN GCC2_HUMAN]] Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.<ref>PMID:16885419</ref> <ref>PMID:17543864</ref> <ref>PMID:17488291</ref>
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[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brunger, A T]]
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[[Category: Brunger AT]]
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[[Category: Burguete, A Schweizer]]
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[[Category: Fenn TD]]
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[[Category: Fenn, T D]]
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[[Category: Pfeffer SR]]
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[[Category: Pfeffer, S R]]
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[[Category: Schweizer Burguete A]]
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[[Category: Acetylation]]
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[[Category: Alternative splicing]]
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[[Category: Arl gtpase]]
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[[Category: Clasp protein]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi apparatus]]
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[[Category: Golgi complex]]
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[[Category: Golgin]]
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[[Category: Grip domain]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Methylation]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Prenylation]]
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[[Category: Protein transport]]
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[[Category: Protein transport-splicing complex]]
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[[Category: Rab effector]]
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[[Category: Rab gtpase]]
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[[Category: Transport]]
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Current revision

Rab6-GTP:GCC185 Rab binding domain complex

PDB ID 3bbp

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