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3btc

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Current revision (12:13, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3btc' size='340' side='right'caption='[[3btc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3btc' size='340' side='right'caption='[[3btc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3btc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BTC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3btc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BTC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGR:MALACHITE+GREEN'>MGR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt6|1jt6]], [[1jup|1jup]], [[1jus|1jus]], [[1jty|1jty]], [[1jum|1jum]], [[1qvt|1qvt]], [[3bt9|3bt9]], [[3bti|3bti]], [[3btj|3btj]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGR:MALACHITE+GREEN'>MGR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">qacR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3btc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3btc OCA], [https://pdbe.org/3btc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3btc RCSB], [https://www.ebi.ac.uk/pdbsum/3btc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3btc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3btc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3btc OCA], [https://pdbe.org/3btc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3btc RCSB], [https://www.ebi.ac.uk/pdbsum/3btc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3btc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
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[https://www.uniprot.org/uniprot/QACR_STAAM QACR_STAAM] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staam]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Brennan, R G]]
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[[Category: Brennan RG]]
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[[Category: Schumacher, M A]]
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[[Category: Schumacher MA]]
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[[Category: Schuman, J T]]
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[[Category: Schuman JT]]
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[[Category: Dna-binding]]
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[[Category: Dye]]
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[[Category: Malachite green]]
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[[Category: Multidrug binding]]
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[[Category: Plasmid]]
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[[Category: Qacr]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

crystal structure of QacR(E57Q) bound to malachite green

PDB ID 3btc

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