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3cow
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3cow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COW FirstGlance]. <br> | <table><tr><td colspan='2'>[[3cow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COW FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=52H:5-O-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTANOYL]SULFAMOYL}ADENOSINE'>52H</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cow OCA], [https://pdbe.org/3cow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cow RCSB], [https://www.ebi.ac.uk/pdbsum/3cow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cow ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cow OCA], [https://pdbe.org/3cow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cow RCSB], [https://www.ebi.ac.uk/pdbsum/3cow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cow ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | + | [[Category: Abell C]] | |
| - | [[Category: Abell | + | [[Category: Blundell TL]] |
| - | [[Category: Blundell | + | [[Category: Chirgadze DY]] |
| - | [[Category: Chirgadze | + | [[Category: Ciulli A]] |
| - | [[Category: Ciulli | + | |
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Current revision
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2
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