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3cwz

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<StructureSection load='3cwz' size='340' side='right'caption='[[3cwz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3cwz' size='340' side='right'caption='[[3cwz]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cwz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bbp|3bbp]], [[2gil|2gil]], [[1d5c|1d5c]], [[2dwk|2dwk]], [[1lox|1lox]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB6A, RAB6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Rab6ip1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [https://pdbe.org/3cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [https://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwz OCA], [https://pdbe.org/3cwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwz RCSB], [https://www.ebi.ac.uk/pdbsum/3cwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[https://www.uniprot.org/uniprot/DEN5A_MOUSE DEN5A_MOUSE]] Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
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[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Goud, B]]
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[[Category: Goud B]]
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[[Category: Houdusse, A]]
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[[Category: Houdusse A]]
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[[Category: Khan, A R]]
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[[Category: Khan AR]]
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[[Category: Recacha, R]]
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[[Category: Recacha R]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi]]
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[[Category: Golgi apparatus]]
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[[Category: Gtp-binding]]
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[[Category: Guanosine 5' triphosphate]]
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[[Category: Lipase]]
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[[Category: Lipoprotein]]
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[[Category: Lipoxygenase]]
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[[Category: Membrane]]
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[[Category: Methylation]]
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[[Category: Nesca plat]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Prenylation]]
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[[Category: Protein transport]]
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[[Category: Rab small gtpase]]
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[[Category: Rab-binding domain]]
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[[Category: Rab6 interacting protein 1]]
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[[Category: Rpip8]]
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[[Category: Run]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Unc-14]]
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Revision as of 13:12, 26 July 2023

Structure of RAB6(GTP)-R6IP1 complex

PDB ID 3cwz

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