This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




3dbc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:44, 30 August 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3dbc' size='340' side='right'caption='[[3dbc]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
<StructureSection load='3dbc' size='340' side='right'caption='[[3dbc]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3dbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3dbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBC FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FR:3-[3-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)PHENYL]PROPANAMIDE'>2FR</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d5w|3d5w]], [[3db6|3db6]], [[3db8|3db8]], [[3dbd|3dbd]], [[3dbe|3dbe]], [[3dbf|3dbf]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FR:3-[3-(3-METHYL-6-{[(1S)-1-PHENYLETHYL]AMINO}-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL)PHENYL]PROPANAMIDE'>2FR</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plk1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbc OCA], [https://pdbe.org/3dbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbc RCSB], [https://www.ebi.ac.uk/pdbsum/3dbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbc OCA], [https://pdbe.org/3dbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbc RCSB], [https://www.ebi.ac.uk/pdbsum/3dbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbc ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q4KMI8_DANRE Q4KMI8_DANRE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 36: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Brachidanio rerio]]
+
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Polo kinase]]
+
[[Category: Barr KJ]]
-
[[Category: Barr, K J]]
+
[[Category: Elling RA]]
-
[[Category: Elling, R A]]
+
[[Category: Romanowski MJ]]
-
[[Category: Romanowski, M J]]
+
[[Category: Zhu J]]
-
[[Category: Zhu, J]]
+
-
[[Category: Catalytic domain]]
+
-
[[Category: Kinase]]
+
-
[[Category: Plk1]]
+
-
[[Category: Polo-like kinase 1]]
+
-
[[Category: Small-molecule inhibitor]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 257

PDB ID 3dbc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools