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3etb

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Current revision (06:33, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3etb' size='340' side='right'caption='[[3etb]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<StructureSection load='3etb' size='340' side='right'caption='[[3etb]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3etb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3etb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3esu|3esu]], [[3esv|3esv]], [[3et9|3et9]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3etb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3etb OCA], [https://pdbe.org/3etb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3etb RCSB], [https://www.ebi.ac.uk/pdbsum/3etb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3etb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3etb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3etb OCA], [https://pdbe.org/3etb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3etb RCSB], [https://www.ebi.ac.uk/pdbsum/3etb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3etb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus anthracis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Barnett, J]]
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[[Category: Barnett J]]
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[[Category: Georgiou, G]]
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[[Category: Georgiou G]]
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[[Category: Iverson, B L]]
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[[Category: Iverson BL]]
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[[Category: Leysath, C E]]
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[[Category: Leysath CE]]
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[[Category: Monzingo, A F]]
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[[Category: Monzingo AF]]
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[[Category: Robertus, J D]]
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[[Category: Robertus JD]]
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[[Category: Antibody-antigen complex]]
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[[Category: Immune system-toxin complex]]
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[[Category: Immunoglobulin]]
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[[Category: Monoclonal antibody]]
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[[Category: Single-chain fv]]
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[[Category: Toxin]]
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Current revision

Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4

PDB ID 3etb

Drag the structure with the mouse to rotate

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