3fb7
From Proteopedia
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<StructureSection load='3fb7' size='340' side='right'caption='[[3fb7]], [[Resolution|resolution]] 3.30Å' scene=''> | <StructureSection load='3fb7' size='340' side='right'caption='[[3fb7]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fb7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3fb7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB7 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr> | |
| - | <tr id=' | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb7 OCA], [https://pdbe.org/3fb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb7 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb7 OCA], [https://pdbe.org/3fb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb7 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Actinomyces lividans krasil'nikov et al. 1965]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Chakrapani | + | [[Category: Streptomyces lividans]] |
| - | [[Category: Cordero-Morales | + | [[Category: Chakrapani S]] |
| - | [[Category: Cortes | + | [[Category: Cordero-Morales JF]] |
| - | [[Category: Cuello | + | [[Category: Cortes DM]] |
| - | [[Category: Gagnon | + | [[Category: Cuello LG]] |
| - | [[Category: Jogini | + | [[Category: Gagnon DH]] |
| - | [[Category: Pan | + | [[Category: Jogini V]] |
| - | [[Category: Perozo | + | [[Category: Pan AC]] |
| - | [[Category: Roux | + | [[Category: Perozo E]] |
| - | + | [[Category: Roux B]] | |
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Revision as of 06:43, 6 September 2023
Open KcsA potassium channel in the presence of Rb+ ion
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