1cd8
From Proteopedia
(New page: 200px<br /> <applet load="1cd8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cd8, resolution 2.6Å" /> '''CRYSTAL STRUCTURE OF...) |
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caption="1cd8, resolution 2.6Å" /> | caption="1cd8, resolution 2.6Å" /> | ||
'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION'''<br /> | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known diseases associated with this structure: CD8 deficiency, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186910 186910]], Megakaryoblastic leukemia, acute OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606078 606078]] |
==About this Structure== | ==About this Structure== | ||
| - | 1CD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1CD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: surface glycoprotein]] | [[Category: surface glycoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:35:17 2008'' |
Revision as of 13:35, 15 February 2008
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CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION
Contents |
Overview
A secreted fragment of the extracellular portion of human CD8 alpha has, been expressed in CHO cells, and a deglycosylated and proteolyzed form of, this fragment has been crystallized. We report here the crystal structure, of this fragment as refined at 2.6 A resolution. The structure was solved, by molecular replacement using a superposition of ten variable domains, from immunoglobulin light chains as the search model. Only the N-terminal, 114 amino acids of CD8 alpha are visible in the electron density maps. The, domain formed by these residues possesses a fold typical of immunoglobulin, variable domains and associates to form Fv-like homodimers.
Disease
Known diseases associated with this structure: CD8 deficiency, familial OMIM:[186910], Megakaryoblastic leukemia, acute OMIM:[606078]
About this Structure
1CD8 is a Single protein structure of sequence from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution., Leahy DJ, Axel R, Hendrickson WA, Cell. 1992 Mar 20;68(6):1145-62. PMID:1547508
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