2c95
From Proteopedia
(Difference between revisions)
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<StructureSection load='2c95' size='340' side='right'caption='[[2c95]], [[Resolution|resolution]] 1.71Å' scene=''> | <StructureSection load='2c95' size='340' side='right'caption='[[2c95]], [[Resolution|resolution]] 1.71Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2c95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2c95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C95 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B4P:BIS(ADENOSINE)-5-TETRAPHOSPHATE'>B4P</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c95 OCA], [https://pdbe.org/2c95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c95 RCSB], [https://www.ebi.ac.uk/pdbsum/2c95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c95 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c95 OCA], [https://pdbe.org/2c95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c95 RCSB], [https://www.ebi.ac.uk/pdbsum/2c95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c95 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:[https://omim.org/entry/612631 612631].<ref>PMID:2542324</ref> <ref>PMID:9432020</ref> <ref>PMID:12649162</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bunkoczi | + | [[Category: Bunkoczi G]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Filippakopoulos | + | [[Category: Jansson A]] |
| - | [[Category: Jansson | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Longman E]] |
| - | [[Category: Longman | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate
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