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2cio

From Proteopedia

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Current revision (14:18, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2cio' size='340' side='right'caption='[[2cio]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2cio' size='340' side='right'caption='[[2cio]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cio]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya] and [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cio]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bp4|1bp4]], [[1bqi|1bqi]], [[1cvz|1cvz]], [[1eff|1eff]], [[1khp|1khp]], [[1khq|1khq]], [[1pad|1pad]], [[1pe6|1pe6]], [[1pip|1pip]], [[1pop|1pop]], [[1ppd|1ppd]], [[1ppn|1ppn]], [[1ppp|1ppp]], [[1stf|1stf]], [[2pad|2pad]], [[4pad|4pad]], [[5pad|5pad]], [[6pad|6pad]], [[9pap|9pap]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Papain Papain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cio OCA], [https://pdbe.org/2cio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cio RCSB], [https://www.ebi.ac.uk/pdbsum/2cio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cio ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cio OCA], [https://pdbe.org/2cio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cio RCSB], [https://www.ebi.ac.uk/pdbsum/2cio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cio ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q868H0_9TRYP Q868H0_9TRYP]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Carica papaya]]
[[Category: Carica papaya]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Papain]]
 
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[[Category: Alphey, M S]]
 
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[[Category: Hunter, W N]]
 
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[[Category: Allergen]]
 
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[[Category: Complex hydrolase-inhibitor]]
 
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[[Category: Cysteine protease]]
 
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[[Category: Hydrolase]]
 
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[[Category: Hydrolase-inhibitor complex]]
 
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[[Category: Hydrolase/inhibitor]]
 
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[[Category: Icp]]
 
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[[Category: Inhibitor]]
 
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[[Category: Protease]]
 
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[[Category: Thiol protease]]
 
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Zymogen]]
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[[Category: Alphey MS]]
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[[Category: Hunter WN]]

Current revision

The high resolution x-ray structure of papain complexed with fragments of the Trypanosoma brucei cysteine protease inhibitor ICP.

PDB ID 2cio

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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