2izt

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Current revision (14:30, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2izt' size='340' side='right'caption='[[2izt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2izt' size='340' side='right'caption='[[2izt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2izt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2izt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23D:N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE'>23D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2chl|2chl]], [[2izr|2izr]], [[2izs|2izs]], [[2izu|2izu]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23D:N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE'>23D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izt OCA], [https://pdbe.org/2izt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izt RCSB], [https://www.ebi.ac.uk/pdbsum/2izt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izt OCA], [https://pdbe.org/2izt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izt RCSB], [https://www.ebi.ac.uk/pdbsum/2izt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN]] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
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[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C]]
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[[Category: Bunkoczi G]]
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[[Category: Bunkoczi, G]]
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[[Category: Das S]]
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[[Category: Das, S]]
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[[Category: Debreczeni JE]]
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[[Category: Debreczeni, J E]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Fedorov O]]
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[[Category: Edwards, A]]
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[[Category: Gileadi O]]
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[[Category: Fedorov, O]]
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[[Category: Knapp S]]
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[[Category: Gileadi, O]]
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[[Category: Rellos P]]
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[[Category: Knapp, S]]
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[[Category: Salah E]]
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[[Category: Rellos, P]]
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[[Category: Savitsky P]]
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[[Category: Salah, E]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Nucleotide-binding]]
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[[Category: Ransferase]]
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[[Category: Transferase]]
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[[Category: Wnt signaling pathway]]
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Current revision

Structure of casein kinase gamma 3 in complex with inhibitor

PDB ID 2izt

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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