2jc6

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Current revision (14:42, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2jc6' size='340' side='right'caption='[[2jc6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2jc6' size='340' side='right'caption='[[2jc6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc6 OCA], [https://pdbe.org/2jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc6 OCA], [https://pdbe.org/2jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN]] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
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[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Bhatia, C]]
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[[Category: Bhatia C]]
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[[Category: Bunkoczi, G]]
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[[Category: Bunkoczi G]]
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[[Category: Colebrook, S]]
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[[Category: Colebrook S]]
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[[Category: Debreczeni, J E]]
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[[Category: Debreczeni JE]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Niesen FH]]
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[[Category: Niesen, F H]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Rellos P]]
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[[Category: Rellos, P]]
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[[Category: Salah E]]
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[[Category: Salah, E]]
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[[Category: Shrestha L]]
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[[Category: Shrestha, L]]
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[[Category: Smee C]]
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[[Category: Smee, C]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Atp-binding]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human calmodulin-dependent protein kinase 1D

PDB ID 2jc6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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