2kbk
From Proteopedia
(Difference between revisions)
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==Solution Structure of BmK-M10== | ==Solution Structure of BmK-M10== | ||
| - | <StructureSection load='2kbk' size='340' side='right'caption='[[2kbk | + | <StructureSection load='2kbk' size='340' side='right'caption='[[2kbk]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [https://pdbe.org/2kbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [https://www.ebi.ac.uk/pdbsum/2kbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [https://pdbe.org/2kbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [https://www.ebi.ac.uk/pdbsum/2kbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SCXA_MESMA SCXA_MESMA] Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbk_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbk_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Wu | + | [[Category: Wu H]] |
| - | [[Category: Zhu | + | [[Category: Zhu J]] |
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Current revision
Solution Structure of BmK-M10
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