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2vjy

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Current revision (15:22, 13 December 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vjy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vjy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALK:(1R)-1-[DIHYDROXY(METHOXY)-LAMBDA^5^-PHOSPHANYL]ETHANOL'>ALK</scene>, <scene name='pdbligand=ALU:METHYL+HYDROGEN+(S)-ACETYLPHOSPHONATE'>ALU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vk4|2vk4]], [[2g1i|2g1i]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALK:(1R)-1-[DIHYDROXY(METHOXY)-LAMBDA^5^-PHOSPHANYL]ETHANOL'>ALK</scene>, <scene name='pdbligand=ALU:METHYL+HYDROGEN+(S)-ACETYLPHOSPHONATE'>ALU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyruvate_decarboxylase Pyruvate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.1 4.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjy OCA], [https://pdbe.org/2vjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vjy RCSB], [https://www.ebi.ac.uk/pdbsum/2vjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjy OCA], [https://pdbe.org/2vjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vjy RCSB], [https://www.ebi.ac.uk/pdbsum/2vjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjy ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDC1_KLULA PDC1_KLULA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Kluyveromyces lactis]]
[[Category: Kluyveromyces lactis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pyruvate decarboxylase]]
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[[Category: Konig S]]
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[[Category: Konig, S]]
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[[Category: Kutter S]]
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[[Category: Kutter, S]]
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[[Category: Weiss MS]]
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[[Category: Weiss, M S]]
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[[Category: Wille G]]
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[[Category: Wille, G]]
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[[Category: Asymmetric active site]]
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[[Category: Decarboxylase]]
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[[Category: Dimer of dimer]]
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[[Category: Flavoprotein]]
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[[Category: Lyase]]
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[[Category: Magnesium]]
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[[Category: Map]]
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[[Category: Metal-binding]]
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[[Category: Methyl acetylphosphonate]]
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[[Category: Methylacetylphosphonate]]
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[[Category: Pyruvate]]
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[[Category: Substrate activation]]
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[[Category: Thiamine diphosphate]]
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[[Category: Thiamine pyrophosphate]]
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Current revision

Pyruvate decarboxylase from Kluyveromyces lactis in complex with the substrate analogue methyl acetylphosphonate

PDB ID 2vjy

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