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1fiv

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[[Image:1fiv.gif|left|200px]]
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{{STRUCTURE_1fiv| PDB=1fiv | SCENE= }}
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'''STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS'''
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===STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS===
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==Overview==
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The crystal structure of a recombinant form of the proteinase encoded by the feline immunodeficiency virus (FIV PR) has been solved at 2 A resolution and refined to an R-factor of 0.148. The refined structure includes a peptidomimetic, statine-based inhibitor, LP-149, which is an even more potent inhibitor of HIV PR. Kinetic parameters were obtained for the cleavage of five substrates by FIV PR, and inhibition constants were measured for four inhibitors. The structure of FIV PR resembles other related retroviral enzymes although few inhibitors of HIV PR are capable of inhibiting FIV PR. The structure of FIV PR will enhance our knowledge of this class of enzymes, and will direct testing of new proteinase inhibitors in a feline animal model.
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(as it appears on PubMed at http://www.pubmed.gov), where 7664111 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664111}}
==About this Structure==
==About this Structure==
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Zdanov, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:22:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:20:09 2008''

Revision as of 00:20, 1 July 2008

Image:1fiv.png

Template:STRUCTURE 1fiv

STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS

Template:ABSTRACT PUBMED 7664111

About this Structure

1FIV is a Single protein structure of sequence from Feline immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus., Wlodawer A, Gustchina A, Reshetnikova L, Lubkowski J, Zdanov A, Hui KY, Angleton EL, Farmerie WG, Goodenow MM, Bhatt D, et al., Nat Struct Biol. 1995 Jun;2(6):480-8. PMID:7664111

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