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1igw

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Current revision (07:54, 15 November 2023) (edit) (undo)
 
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<StructureSection load='1igw' size='340' side='right'caption='[[1igw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1igw' size='340' side='right'caption='[[1igw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1igw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IGW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1igw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IGW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aceA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.1 4.1.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1igw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1igw OCA], [https://pdbe.org/1igw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1igw RCSB], [https://www.ebi.ac.uk/pdbsum/1igw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1igw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1igw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1igw OCA], [https://pdbe.org/1igw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1igw RCSB], [https://www.ebi.ac.uk/pdbsum/1igw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1igw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACEA_ECOLI ACEA_ECOLI]] Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).
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[https://www.uniprot.org/uniprot/ACEA_ECOLI ACEA_ECOLI] Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Isocitrate lyase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abeysinghe, I S.B]]
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[[Category: Abeysinghe ISB]]
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[[Category: Baker, P J]]
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[[Category: Baker PJ]]
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[[Category: Barynin, V]]
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[[Category: Barynin V]]
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[[Category: Britton, K L]]
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[[Category: Britton KL]]
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[[Category: Diehl, P]]
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[[Category: Diehl P]]
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[[Category: Langridge, S J]]
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[[Category: Langridge SJ]]
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[[Category: McFadden, B A]]
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[[Category: McFadden BA]]
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[[Category: Rice, D W]]
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[[Category: Rice DW]]
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[[Category: Sedelnikova, S E]]
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[[Category: Sedelnikova SE]]
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[[Category: Stillman, T J]]
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[[Category: Stillman TJ]]
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[[Category: Weeradechapon, K]]
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[[Category: Weeradechapon K]]
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[[Category: Beta barrel]]
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[[Category: Lyase]]
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Current revision

Crystal Structure of the Isocitrate Lyase from the A219C mutant of Escherichia coli

PDB ID 1igw

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