1fjl

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[[Image:1fjl.gif|left|200px]]
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{{STRUCTURE_1fjl| PDB=1fjl | SCENE= }}
{{STRUCTURE_1fjl| PDB=1fjl | SCENE= }}
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'''HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE'''
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===HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE===
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==Overview==
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The crystal structure of the paired homeodomain bound to DNA as a cooperative dimer has been determined to 2.0 A resolution. Direct contacts between each homeodomain and the DNA are similar to those described previously. In addition, an extensive network of water molecules mediates contacts between the recognition helix and the DNA major groove. Several symmetrical contacts between the two homeodomains underlie the cooperative interaction, and deformations in the DNA structure are necessary for the establishment of these contacts. Comparison with structures of homeodomains bound monomerically to DNA suggests that the binding of a single paired homeodomain can introduce these DNA distortions, thus preparing a template for the cooperative interaction with a second homeodomain. This study shows how the paired (Pax) class homeodomains have achieved cooperativity in DNA binding without the assistance of other domains, thereby enabling the recognition of target sequences that are long enough to ensure specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_7671301}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7671301 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7671301}}
==About this Structure==
==About this Structure==
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[[Category: Paired box]]
[[Category: Paired box]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:22:09 2008''

Revision as of 00:22, 1 July 2008

Image:1fjl.png

Template:STRUCTURE 1fjl

HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE

Template:ABSTRACT PUBMED 7671301

About this Structure

1FJL is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA., Wilson DS, Guenther B, Desplan C, Kuriyan J, Cell. 1995 Sep 8;82(5):709-19. PMID:7671301

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