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1fjm

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[[Image:1fjm.gif|left|200px]]
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{{Seed}}
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[[Image:1fjm.png|left|200px]]
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{{STRUCTURE_1fjm| PDB=1fjm | SCENE= }}
{{STRUCTURE_1fjm| PDB=1fjm | SCENE= }}
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'''PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN'''
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===PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN===
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==Overview==
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The crystal structure of mammalian protein phosphatase-1, complexed with the toxin microcystin and determined at 2.1 A resolution, reveals that it is a metalloenzyme unrelated in architecture to the tyrosine phosphatases. Two metal ions are positioned by a central beta-alpha-beta-alpha-beta scaffold at the active site, from which emanate three surface grooves that are potential binding sites for substrates and inhibitors. The carboxy terminus is positioned at the end of one of the grooves such that regulatory sequences following the domain might modulate function. The fold of the catalytic domain is expected to be closely preserved in protein phosphatases 2A and 2B (calcineurin).
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The line below this paragraph, {{ABSTRACT_PUBMED_7651533}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7651533 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7651533}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:22:12 2008''

Revision as of 00:22, 1 July 2008

Image:1fjm.png

Template:STRUCTURE 1fjm

PROTEIN SERINE/THREONINE PHOSPHATASE-1 (ALPHA ISOFORM, TYPE I) COMPLEXED WITH MICROCYSTIN-LR TOXIN

Template:ABSTRACT PUBMED 7651533

About this Structure

1FJM is a Single protein structure of sequence from Microcystis aeruginosa and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1., Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, Kuriyan J, Nature. 1995 Aug 31;376(6543):745-53. PMID:7651533

Page seeded by OCA on Tue Jul 1 03:22:12 2008

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