1fjr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fjr.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1fjr.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fjr| PDB=1fjr | SCENE= }}
{{STRUCTURE_1fjr| PDB=1fjr | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE ECTODOMAIN OF METHUSELAH'''
+
===CRYSTAL STRUCTURE OF THE ECTODOMAIN OF METHUSELAH===
-
==Overview==
+
<!--
-
The Drosophila mutant methuselah (mth) was identified from a screen for single gene mutations that extended average lifespan. Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. Here we report the 2.3-A resolution crystal structure of the Mth extracellular region, revealing a folding topology in which three primarily beta-structure-containing domains meet to form a shallow interdomain groove containing a solvent-exposed tryptophan that may represent a ligand binding site. The Mth structure is analyzed in relation to predicted Mth homologs and potential ligand binding features.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11274391}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11274391 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11274391}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: G protein-coupled receptor]]
[[Category: G protein-coupled receptor]]
[[Category: Gpcr]]
[[Category: Gpcr]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:22:29 2008''

Revision as of 00:22, 1 July 2008

Image:1fjr.png

Template:STRUCTURE 1fjr

CRYSTAL STRUCTURE OF THE ECTODOMAIN OF METHUSELAH

Template:ABSTRACT PUBMED 11274391

About this Structure

1FJR is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan., West AP Jr, Llamas LL, Snow PM, Benzer S, Bjorkman PJ, Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3744-9. Epub 2001 Mar 13. PMID:11274391

Page seeded by OCA on Tue Jul 1 03:22:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fjr"
Personal tools