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1wb0

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Current revision (13:26, 13 December 2023) (edit) (undo)
 
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<StructureSection load='1wb0' size='340' side='right'caption='[[1wb0]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='1wb0' size='340' side='right'caption='[[1wb0]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wb0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WB0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wb0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WB0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=VR0:N~5~-[N-(METHYLCARBAMOYL)CARBAMIMIDOYL]-L-ORNITHINE'>VR0</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VR0:N~5~-[N-(METHYLCARBAMOYL)CARBAMIMIDOYL]-L-ORNITHINE'>VR0</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1guv|1guv]], [[1hki|1hki]], [[1hkj|1hkj]], [[1hkk|1hkk]], [[1hkm|1hkm]], [[1lg1|1lg1]], [[1lg2|1lg2]], [[1lq0|1lq0]], [[1waw|1waw]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wb0 OCA], [https://pdbe.org/1wb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wb0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wb0 OCA], [https://pdbe.org/1wb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wb0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN]] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
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[https://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chitinase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aalten, D M.F Van]]
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[[Category: Synthetic construct]]
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[[Category: Adams, D J]]
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[[Category: Adams DJ]]
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[[Category: Aerts, J M.F G]]
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[[Category: Aerts JMFG]]
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[[Category: Boot, R G]]
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[[Category: Boot RG]]
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[[Category: Hodkinson, M]]
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[[Category: Hodkinson M]]
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[[Category: Houston, D R]]
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[[Category: Houston DR]]
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[[Category: Omura, S]]
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[[Category: Omura S]]
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[[Category: Rao, F V]]
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[[Category: Rao FV]]
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[[Category: Shiomi, K]]
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[[Category: Shiomi K]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Van Aalten DMF]]
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[[Category: Chitin degradation]]
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[[Category: Chitin-binding]]
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[[Category: Chitinase inhibitor]]
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[[Category: Cyclopentapeptide inhibitor]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

specificity and affinity of natural product cyclopentapeptide inhibitor Argifin against human chitinase

PDB ID 1wb0

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