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1wut

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Current revision (13:50, 9 May 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUT FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BN2:7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC+ACID'>BN2</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c50|1c50]], [[1wuy|1wuy]], [[1wv0|1wv0]], [[1wv1|1wv1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BN2:7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC+ACID'>BN2</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wut OCA], [https://pdbe.org/1wut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wut RCSB], [https://www.ebi.ac.uk/pdbsum/1wut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wut ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wut OCA], [https://pdbe.org/1wut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wut RCSB], [https://www.ebi.ac.uk/pdbsum/1wut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wut ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
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[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Phosphorylase]]
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[[Category: Brachvogel V]]
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[[Category: Brachvogel, V]]
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[[Category: Burger H-J]]
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[[Category: Burger, H J]]
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[[Category: Defossa E]]
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[[Category: Defossa, E]]
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[[Category: Herling AW]]
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[[Category: Herling, A W]]
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[[Category: Kadereit D]]
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[[Category: Kadereit, D]]
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[[Category: Klabunde T]]
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[[Category: Klabunde, T]]
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[[Category: Kosmopoulou MN]]
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[[Category: Kosmopoulou, M N]]
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[[Category: Oikonomakos NG]]
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[[Category: Oikonomakos, N G]]
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[[Category: Sarubbi E]]
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[[Category: Roedern, E von]]
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[[Category: Schmoll D]]
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[[Category: Sarubbi, E]]
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[[Category: Schonafinger K]]
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[[Category: Schmoll, D]]
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[[Category: Wendt KU]]
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[[Category: Schonafinger, K]]
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[[Category: Von Roedern E]]
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[[Category: Wendt, K U]]
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[[Category: Glycogenolysis]]
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[[Category: Transferase]]
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[[Category: Type 2 diabetes]]
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Current revision

Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes

PDB ID 1wut

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