1wxl
From Proteopedia
(Difference between revisions)
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==Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT== | ==Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT== | ||
| - | <StructureSection load='1wxl' size='340' side='right'caption='[[1wxl | + | <StructureSection load='1wxl' size='340' side='right'caption='[[1wxl]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxl OCA], [https://pdbe.org/1wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxl RCSB], [https://www.ebi.ac.uk/pdbsum/1wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxl ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxl OCA], [https://pdbe.org/1wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxl RCSB], [https://www.ebi.ac.uk/pdbsum/1wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SSRP1_DROME SSRP1_DROME] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.<ref>PMID:12815073</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Drosophila melanogaster]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hirose | + | [[Category: Hirose S]] |
| - | [[Category: Kasai | + | [[Category: Kasai N]] |
| - | [[Category: Morikawa | + | [[Category: Morikawa K]] |
| - | [[Category: Ohki | + | [[Category: Ohki I]] |
| - | [[Category: Tate | + | [[Category: Tate S]] |
| - | [[Category: Tsunaka | + | [[Category: Tsunaka Y]] |
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Current revision
Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT
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