1x5v

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Current revision (09:29, 6 December 2023) (edit) (undo)
 
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==NMR Structure of PcFK1==
==NMR Structure of PcFK1==
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<StructureSection load='1x5v' size='340' side='right'caption='[[1x5v]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='1x5v' size='340' side='right'caption='[[1x5v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Psaca Psaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Psalmopoeus_cambridgei Psalmopoeus cambridgei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5V FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5v OCA], [https://pdbe.org/1x5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5v RCSB], [https://www.ebi.ac.uk/pdbsum/1x5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5v OCA], [https://pdbe.org/1x5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5v RCSB], [https://www.ebi.ac.uk/pdbsum/1x5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TXFK1_PSACA TXFK1_PSACA]] Possess strong antiplasmodial activity against the intra-erythrocyte stage of P.falciparum in vitro. IC(50) for inhibiting P.falciparum growth is 1.59 uM. Interacts with infected and healthy erythrocytes. Does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. Has neither antibacterial nor antifungal activity.<ref>PMID:15304333</ref>
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[https://www.uniprot.org/uniprot/NTA_PSACA NTA_PSACA] Possesses strong antiplasmodial activity against the intra-erythrocyte stage of P.falciparum in vitro. IC(50) for inhibiting P.falciparum growth is 1.59 uM. Interacts with infected and healthy erythrocytes. Does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. Has neither antibacterial nor antifungal activity.<ref>PMID:15304333</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Psaca]]
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[[Category: Psalmopoeus cambridgei]]
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[[Category: Camadro, J M]]
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[[Category: Camadro JM]]
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[[Category: Chagot, B]]
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[[Category: Chagot B]]
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[[Category: Choi, S J]]
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[[Category: Choi SJ]]
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[[Category: Darbon, H]]
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[[Category: Darbon H]]
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[[Category: Guette, C]]
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[[Category: Guette C]]
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[[Category: Pimentel, C]]
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[[Category: Pimentel C]]
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[[Category: Inhibitory cystine knot]]
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[[Category: Toxin]]
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Current revision

NMR Structure of PcFK1

PDB ID 1x5v

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