1fl8

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[[Image:1fl8.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1fl8| PDB=1fl8 | SCENE= }}
{{STRUCTURE_1fl8| PDB=1fl8 | SCENE= }}
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'''HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE'''
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===HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE===
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==Overview==
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Modified nucleosides in the anticodon domain of Escherichia coli tRNA(Lys) are necessary for high-affinity codon recognition and reading frame maintenance. Human tRNA(Lys,3) is the specific primer for HIV-1 reverse transcriptase and also requires nucleoside modification for proper function. We now present NMR solution structures for the fully modified 17-nucleotide E. coli tRNA(Lys) anticodon stem-loop domain (ASL). NMR data were also collected for several partially modified ASLs, revealing the contributions each modified nucleoside (mnm(5)s(2)U34, t(6)A37, and psi39) makes in transforming the disordered, unmodified tRNA ASL into the highly ordered native structure. The solution structure of the native ASL domain provides insight into longstanding questions regarding both wobble position modification and the nearly ubiquitous t(6)A37 found in tRNAs with an adjacent U at position 36. Native tRNA(Lys) has a U-turn structure similar to the yeast tRNA(Phe) crystal structure, unlike previously proposed "unconventional" anticodon structures characterized by stable interactions between mnm(5)s(2)U-34 and t(6)A-37.
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The line below this paragraph, {{ABSTRACT_PUBMED_11027137}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11027137 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11027137}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL8 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL8 OCA].
==Reference==
==Reference==
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[[Category: T6a]]
[[Category: T6a]]
[[Category: Trna]]
[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:27:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:26:02 2008''

Revision as of 00:26, 1 July 2008

Image:1fl8.png

Template:STRUCTURE 1fl8

HYPERMODIFIED NUCLEOSIDES IN THE ANTICODON OF TRNALYS STABILIZE A CANONICAL U-TURN STRUCTURE

Template:ABSTRACT PUBMED 11027137

About this Structure

Full experimental information is available from OCA.

Reference

Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure., Sundaram M, Durant PC, Davis DR, Biochemistry. 2000 Oct 17;39(41):12575-84. PMID:11027137

Page seeded by OCA on Tue Jul 1 03:26:02 2008

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