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7dee
From Proteopedia
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| - | ==== | + | ==Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8== |
<StructureSection load='7dee' size='340' side='right'caption='[[7dee]]' scene=''> | <StructureSection load='7dee' size='340' side='right'caption='[[7dee]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7dee]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DEE FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dee OCA], [https://pdbe.org/7dee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dee RCSB], [https://www.ebi.ac.uk/pdbsum/7dee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dee ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dee OCA], [https://pdbe.org/7dee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dee RCSB], [https://www.ebi.ac.uk/pdbsum/7dee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dee ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Bai ZQ]] |
| + | [[Category: Hu KF]] | ||
Current revision
Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8
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