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1y8t
From Proteopedia
(Difference between revisions)
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<StructureSection load='1y8t' size='340' side='right'caption='[[1y8t]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1y8t' size='340' side='right'caption='[[1y8t]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1y8t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1y8t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8T FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8t OCA], [https://pdbe.org/1y8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8t RCSB], [https://www.ebi.ac.uk/pdbsum/1y8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8t ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y8t TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8t OCA], [https://pdbe.org/1y8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8t RCSB], [https://www.ebi.ac.uk/pdbsum/1y8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8t ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y8t TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PEPD_MYCTU PEPD_MYCTU] Required for virulence (PubMed:18479146). Acts both as a protease, which degrades and/or refolds damaged substrate targets, and as a chaperone (PubMed:18479146, PubMed:20061478). Plays an important role in the stress response network mediated through the two-component regulatory system MprAB and SigE signaling networks (PubMed:20061478). May utilize its PDZ domain to recognize and process misfolded proteins at the cell membrane, leading to activation of the MprAB and SigE signaling pathways and subsequent establishment of a positive feedback loop that facilitates bacterial adaptation (PubMed:20061478). Interacts with and potentially cleaves several proteins, including the 35 kDa antigen PspA (PubMed:21445360). Proteolytic cleavage of PspA may help to maintain cell envelope homeostasis in Mycobacterium and regulate specific stress response pathways during periods of extracytoplasmic stress (PubMed:21445360). In vitro, exhibits proteolytic activity against the artificial substrate beta-casein (PubMed:18479146, PubMed:20061478).<ref>PMID:18479146</ref> <ref>PMID:20061478</ref> <ref>PMID:21445360</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8t ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8t ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: MohamedMohaideen | + | [[Category: MohamedMohaideen NN]] |
| - | [[Category: Palaninathan | + | [[Category: Palaninathan SK]] |
| - | [[Category: Sacchettini | + | [[Category: Sacchettini JC]] |
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Current revision
Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form
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