1fmk

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{{STRUCTURE_1fmk| PDB=1fmk | SCENE= }}
{{STRUCTURE_1fmk| PDB=1fmk | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''
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===CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC===
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==Overview==
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The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.
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(as it appears on PubMed at http://www.pubmed.gov), where 9024657 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9024657}}
==About this Structure==
==About this Structure==
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[[Category: Src]]
[[Category: Src]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:30:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:30:01 2008''

Revision as of 00:30, 1 July 2008

Image:1fmk.png

Template:STRUCTURE 1fmk

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC

Template:ABSTRACT PUBMED 9024657

About this Structure

1FMK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:9024657

Page seeded by OCA on Tue Jul 1 03:30:01 2008

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